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目的通过分析前列腺癌的ADC值与病理Gleason评分的相关性,探讨MR扩散加权成像(DWI)对前列腺癌生物学特性的评估价值。资料与方法 40例前列腺癌行MR DWI扫描,b值为800 s/mm2。测量各病例的表观扩散系数(ADC)值,并与病理Gleason评分进行对照,统计分析是否存在差异性以及相关性分析。结果 40例前列腺癌Gleason评分5~6分,7分,8~10分分别为11例,14例,15例,平均ADC值分别为(1.11±0.24)×10-3mm2/s、(0.96±0.27)×10-3mm2/s及(0.83±0.13)×10-3mm2/s,经方差分析有统计学意义(F=3.69,P<0.05);前列腺癌的ADC值与Gleason评分呈负相关(r=-0.43,P<0.05)。结论前列腺癌的ADC值与Gleason评分呈负相关,ADC值有可能作为非侵袭性手段来判断前列腺癌的生物学特性及其预后。
Objective To evaluate the value of MR diffusion weighted imaging (DWI) in evaluating the biological characteristics of prostate cancer by analyzing the correlation between the ADC value of the prostate cancer and the pathological Gleason score. Materials and Methods Forty cases of prostate cancer underwent MR DWI scanning with a b value of 800 s / mm2. Apparent diffusion coefficient (ADC) value of each case was measured, and compared with the pathological Gleason score, statistical analysis of the existence of differences and correlation analysis. Results The Gleason score of 40 cases of prostate cancer was 5 to 6, 7 and 8 to 11 respectively, 14 and 15, respectively, and the average ADC values were (1.11 ± 0.24) × 10-3mm2 / s and (0.96 ± 0.27) × 10-3mm2 / s and (0.83 ± 0.13) × 10-3mm2 / s respectively, with statistical significance (F = 3.69, P <0.05). ADC value of prostate cancer was negatively correlated with Gleason score r = -0.43, P <0.05). Conclusion ADC value of prostate cancer is negatively correlated with Gleason score. ADC value may be used as a noninvasive means to judge the biological characteristics of prostate cancer and its prognosis.