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目的探讨不同亚型的CD4+T淋巴细胞在干扰素抗乙肝病毒治疗中的作用。方法采用酶联免疫吸附试验(ELISA)法测定54例慢性乙型肝炎患者应用普通干扰素治疗(500万单位,隔日皮下注射1次)前和治疗24周后血清中辅助性T淋巴细胞(Th)17、1、2分泌的主要细胞因子白细胞介素17(IL-17)、γ干扰素(IFN-γ)、白细胞介素4(IL-4)的水平,并根据应答的不同进行分组,分析不同亚型CD4+T淋巴细胞的作用。结果慢性乙型肝炎患者经普通干扰素治疗24周后IL-17水平下降(P>0.05),IFN-γ水平上升(P>0.05),IL-4水平明显下降(P<0.01)。而在干扰素治疗的完全应答组,IL-17、IL-4水平下降更明显(P<0.05、P<0.01),IFN-γ水平则明显升高(P<0.01)。结论慢性乙型肝炎患者经干扰素抗病毒治疗,体内Th17和Th2的功能下调,Th1功能上调。
Objective To investigate the role of different subtypes of CD4 + T lymphocytes in interferon treatment of hepatitis B virus. Methods Serum levels of helper T lymphocytes (Th (superscript +)) in 54 patients with chronic hepatitis B before and after 24 weeks were measured by enzyme linked immunosorbent assay (ELISA) ) Levels of major cytokines IL-17, IFN-γ and IL-4 secreted by 17,1,2 were grouped according to the different responses, Analyze the role of different subtypes of CD4 + T lymphocytes. Results The level of IL-17 was decreased (P> 0.05), the level of IFN-γ was increased (P> 0.05) and the level of IL-4 was decreased significantly (P <0.01) in patients with chronic hepatitis B after 24 weeks of general interferon treatment. However, the levels of IL-17 and IL-4 in the complete response group were significantly decreased (P <0.05, P <0.01) and the level of IFN-γ significantly increased in the interferon-treated complete response group (P <0.01). Conclusion Interferon antiviral therapy in patients with chronic hepatitis B, the function of Th17 and Th2 downregulation, Th1 function upregulation.