论文部分内容阅读
酮康唑(Ketoconazole)是继灰黄霉素后在系统性抗真菌剂方面的一个重大发现,且其抗菌谱大大超过灰黄霉素。近几年来,还发现酮康唑的作用已远远超出了抗真菌的范围,并且在医药界引起了广泛的关注。这些特殊作用有的与皮肤科直接有关,有的则可作为应用酮康唑时的重要参考。现将酮康唑抗真菌和抗原虫以外的特殊作用综述如下: 一、对胆固醇合成的作用:酮康唑对真菌的作用主要是抑制麦角固醇的合成,因为后者是真菌细胞膜的主要固醇。酮康唑也抑制哺乳动物细胞膜的固醇,主要是胆固醇的合成,虽然这一抑制作用比对麦角固醇小
Ketoconazole is a major discovery in the area of systemic antifungal agents following griseofulvin, and its antibacterial spectrum significantly exceeds that of griseofulvin. In recent years, it has been found that the action of ketoconazole has far exceeded the scope of anti-fungal and has aroused widespread concern in the pharmaceutical industry. Some of these special effects and dermatology directly related, and some can be used as an important reference when the application of ketoconazole. The specific effects of ketoconazole other than antifungal and antigenic worms are summarized as follows: 1. The effect on cholesterol synthesis: The effect of ketoconazole on fungi is mainly to inhibit the synthesis of ergosterol, which is the major solid of the fungal cell membrane alcohol. Ketoconazole also inhibits mammalian cell membrane sterols, mainly the synthesis of cholesterol, though this inhibition is less pronounced than with ergosterol