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目的:分析多囊卵巢综合征(PCOS)患者的临床特征及生化改变。方法:回顾性分析1 273例PCOS患者的临床特征及内分泌、血糖、血脂、胰岛素等检查指标。结果:1 273例PCOS患者中,85.31%存在月经改变,82.95%患不孕症,16.58%存在高雄激素血症临床表现,38.49%伴肥胖,18.38%伴超重,93.09%阴道B超示PCO征,9.19%合并糖耐量受损,2.28%合并糖尿病,54.05%伴脂代谢异常。有月经改变的PCOS患者,易发生不孕,且血清雄烯二酮水平升高(P<0.05);存在高雄激素血症临床表现的PCOS患者,其HOMA-IR显著升高,但不易发生月经改变、不孕和PCO(P<0.05);B超显示PCO征的PCOS患者,易患不孕,且雄烯二酮水平及BMI均显著高于无PCO征者(P<0.05)。结论:育龄期PCOS患者多以月经失调和PCO征为主要表现,临床高雄激素血症比例较低。育龄期PCOS患者有月经改变或PCO征者易合并不孕,而高雄激素血症临床表现明显者易发生糖代谢紊乱。
Objective: To analyze the clinical characteristics and biochemical changes of patients with polycystic ovary syndrome (PCOS). Methods: A retrospective analysis of 1 273 PCOS patients with clinical features and endocrine, blood glucose, lipids, insulin and other indicators. Results: Among the 2773 PCOS patients, 85.31% had menstrual changes, 82.95% had infertility, 16.58% had hyperandrogenism clinical manifestations, 38.49% with obesity, 18.38% with overweight and 93.09% with vaginal B- , 9.19% with impaired glucose tolerance, 2.28% with diabetes, and 54.05% with dyslipidemia. PCOS patients with menstrual changes, prone to infertility, and serum levels of androstenedione (P <0.05); the presence of hyperandrogenism PCOS patients with clinical manifestations, the HOMA-IR increased significantly, but not prone to menstruation (P <0.05). The PCOS patients with B-ultrasound showed PCO were predisposed to infertility, and the levels of androstenedione and BMI were significantly higher than those without PCO (P <0.05). Conclusions: Most PCOS patients of childbearing age mainly show menstrual disorders and PCO sign. The proportion of patients with hyperandrogenism is low. Childbearing age PCOS patients with menstruation or PCO levy easily combined with infertility, and hyperandrogenism clinical manifestations were prone to disorders of glucose metabolism.