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近年来，细胞因子在小儿过敏性紫癜发病机理中的作用日益受到重视。为探讨肿瘤坏死因子（TNFa）在小儿过敏性紫癜中的变化，我们采用双抗夹心ELISA法对30例过敏性紫癜患儿急性期血浆肿瘤坏死因子水平进行了测定。结果显示：过敏性紫癜患儿急性期的血浆TNF。水平较正常对照组明显升高，且与临床血管炎严重程度成正比。提示TNF。在小儿过敏性紫癜血管炎的形成过程中可能起重要作用。
In recent years, the role of cytokines in the pathogenesis of allergic purpura in children has received increasing attention. In order to investigate the changes of tumor necrosis factor (TNFa) in children with Henoch-Schonlein purpura, we measured the levels of plasma tumor necrosis factor-α (TNF-α) in 30 children with Henoch-Schonlein purpura using double-antibody sandwich ELISA. The results show that: acute purpura in children with plasma TNF. The level was significantly higher than the normal control group, and is proportional to the severity of clinical vasculitis. Tip TNF. In pediatric allergic purpura vasculitis may play an important role in the formation process.