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目的:探讨骨桥蛋白(OPN)、整合素ανβ3在子宫内膜癌的发生、发展中的作用。方法:采用免疫组织化学SP染色法。对20例正常增生期子宫内膜组织(NE)、20例子宫内膜不典型增生组织(AH)及45例子宫内膜腺癌组织(EC)中的OPN、整合素ανβ3表达进行检测,并评价其与子宫内膜腺癌临床病理特征的关系。结果:OPN和整合素ανβ3在NE、AH、EC中的阳性表达率分别为30.0%、45.0%、86.7%;15.0%、40.0%、75.6%;二者的表达从NE到EC的发展过程中逐渐增高;二者的表达随着子宫内膜腺癌的分化降低而增加,随临床分期、肌层浸润及淋巴结转移等方面的发展,其表达均显著增加,二者在EC中的表达呈正相关性。结论:①OPN和整合素ανβ3在EC中呈明显阳性表达,二者的表达与肿瘤的恶性程度呈明显的正相关。②EC中OPN、ανβ3表达呈正相关,同时检测OPN和整合素ανβ3有望提高子宫内膜癌的检出率及预测预后。
Objective: To investigate the role of osteopontin (OPN) and integrin ανβ3 in the development and progression of endometrial carcinoma. Methods: Immunohistochemical SP staining was used. The expression of OPN and integrin αvβ3 in 20 cases of normal proliferative endometrial tissue (NE), 20 cases of endometrial dysplasia (AH) and 45 cases of endometrial adenocarcinoma (EC) were detected and analyzed Evaluate its relationship with clinicopathological features of endometrial adenocarcinoma. RESULTS: The positive rates of OPN and integrin ανβ3 in NE, AH and EC were 30.0%, 45.0% and 86.7%, respectively. The expressions of OPN and ECV were both 15.0%, 40.0% and 75.6% Gradually increased; the expression of both increased with the differentiation of endometrial adenocarcinoma, with the clinical stage, myometrial invasion and lymph node metastasis and other aspects of the development were significantly increased, both in EC expression was positively correlated Sex. CONCLUSION: ① The expression of OPN and integrin ανβ3 is obviously positive in EC, and the expression of OPN and integrin ανβ3 is positively correlated with the malignant degree of tumor. ② The expression of OPN and ανβ3 in EC was positively correlated with the detection of OPN and integrin ανβ3, which could increase the detection rate of endometrial cancer and predict the prognosis.