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1.一九七三年3—6月,我们对成都地区30岁以上543例正常人作血脂分析及脂蛋白分型电泳时,发现高脂血症60例,经询问病史、查体、心电图及尿糖、蛋白检查,未发现异常。2.成都地区30岁以上正常人中原因不明的高脂血症相对发病率为11%,高胆固醇血症(胆固醇>280毫克%)相对发病率为1.1%,高甘油三酯血症(甘油三酯>200毫克%)相对发病率为9.4%。3.按 Fredrickson 分型原则分型,60例高脂蛋白血症以Ⅳ型为最多,占65.0%;Ⅱ型次之占25%,共中Ⅱa 型占13.3%,Ⅱb 型占11.7%;Ⅴ型及Ⅲ型甚少分别占6.7%及3.3%。4.对各型高脂蛋白血症血脂的化学组成及醋酸纤维薄膜脂蛋白电泳组成及相对含量特点进行了分析,其中以胆固醇及甘油三酯含量,特别是胆固醇/甘油三酯比值和脂蛋白分型电泳对鉴别各型高脂蛋白血症意义最大。5.我们共得Ⅳ型高脂蛋白血症99例,冠心病相对发病率为51.5%,Ⅱ型高脂蛋白血症61例,冠心病相对发病率为75.0%。6.结合文献对高脂血症的概念、分型、病因、发病机制、临床表现、诊断及治疗原则进行了讨论。
1. From March to June 1973, we analyzed lipid profiles and lipoprotein typing in 543 normal people over the age of 30. We found 60 cases of hyperlipidemia. After inquiry of medical history, physical examination, electrocardiogram And urine sugar, protein check, found no abnormalities. 2. In Chengdu, the relative incidence of unidentified hyperlipidemia in 11-year-olds was 11% and the relative incidence of hypercholesterolemia (cholesterol> 280 mg%) was 1.1%. Hypertriglyceridemia (glycerol Triester> 200 mg%) had a relative incidence of 9.4%. According to the classification principle of Fredrickson classification, 60 cases of hyperlipoproteinemia accounted for 65.0% of type IV, 25% of type II, 13.3% of type IIa and 11.7% of type IIb; Type and type Ⅲ rarely accounted for 6.7% and 3.3%. The chemical composition of the lipids in various types of hyperlipoproteinemia and the composition and relative content of the acetate lipoprotein electrophoresis were analyzed. Cholesterol and triglyceride content, especially cholesterol / triglyceride ratio and lipoprotein Typing electrophoresis to identify the most significant of all types of hyperlipoproteinemia. 5. We obtained 99 cases of type Ⅳ hyperlipoproteinemia, the relative incidence of coronary heart disease was 51.5%, type Ⅱ hyperlipoproteinemia in 61 cases, the relative incidence of coronary heart disease was 75.0%. 6. With the literature on the concept of hyperlipidemia, typing, etiology, pathogenesis, clinical manifestations, diagnosis and treatment principles were discussed.