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目的比较观察阿托伐他汀钙强化和常规治疗对颈动脉粥样硬化斑块的临床疗效和安全性。方法选择经颈部彩色多普勒超声检查颈动脉内膜-中膜厚度(IMT)>1.2 mm的粥样斑块病变为靶病变,将80例颈动脉粥样硬化斑块患者随机分为阿托伐他汀钙40 mg/d的强化治疗组和阿托伐他汀钙20 mg/d的常规对照组,9个月后再次行颈部超声,比较治疗前后斑块数目、IMT及颈动脉粥样硬化斑块面积。结果 80例均完成了临床随访,68例完成了整个服药过程及颈部超声复查。9个月后常规对照组靶病变斑块IMT值及斑块面积未见明显改变(P>0.05),而强化治疗组靶病变斑块IMT值及斑块面积明显降低(P<0.05)。结论阿托伐他汀钙强化治疗组可遏制颈动脉粥样硬化斑块的进展。
Objective To observe the clinical efficacy and safety of atorvastatin calcium fortification and routine treatment on carotid atherosclerosis plaque. Methods Eighty patients with carotid atherosclerotic plaques were randomly divided into two groups according to color Doppler echocardiography of carotid intima - media thickness (IMT)> 1.2 mm in atherosclerotic lesions. Atorvastatin 40 mg / d intensive treatment group and atorvastatin calcium 20 mg / d conventional control group, neck ultrasound again 9 months later, the number of plaques before and after treatment, IMT and carotid atherosclerosis Hardened plaque area. Results 80 cases completed the clinical follow-up, 68 cases completed the medication and neck ultrasound review. After 9 months, IMT and plaque area of target lesion in routine control group showed no significant change (P> 0.05), but IMT value and plaque area in target lesion in treatment group decreased significantly (P <0.05). Conclusions Atorvastatin calcium-fortified group can restrain the progression of carotid atherosclerosis plaque.