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目的 :研究基膜蛋白在涎腺腺样囊性癌 (ACC)中的表达特征 ,并探讨其与 ACC细胞分化程度及预后的关系。方法 :选取经病理证实为 ACC的 10 1例病例 ,进行临床病理资料分析及随访。然后选取其中 3 0例进行基膜蛋白的免疫组织化学标记。结果 :1ACC实体型及含有该成分的混合型 ACC患者预后较差 ,发生转移或 (和 )复发的比例较高 ,且 ACC局部复发比远处转移更为多见。 2 ACC基膜的存在部位及阳性表达程度与其类型有关 ,阳性程度以筛状型表达最高 ,管状型次之 ,实体型最差。此外 ,筛状型 ACC中 ,有转移或 (和 )复发的病例阳性表达低。 3 4种基膜蛋白中 ,纤维粘连蛋白在各类型 ACC中的表达均较差。结论 :1基膜蛋白的阳性表达程度与 ACC的恶性程度呈负相关。基膜蛋白可作为评估患者预后的依据之一。 2在参与组成基膜的物质中 ,基膜粘连蛋白可能是肿瘤实质细胞与基膜胶原粘附的主要物质。
Objective: To study the expression characteristics of basement membrane protein in adenoid cystic carcinoma (ACC) and to explore its relationship with the differentiation and prognosis of ACC cells. Methods : One hundred and one patients with pathologically confirmed ACC were selected for clinical pathological analysis and follow-up. Then 30 of them were selected to perform immunohistochemical labeling of basement membrane proteins. RESULTS: 1ACC solid type and mixed ACC patients with this component had a poorer prognosis, with a higher proportion of metastases or (and) recurrences, and local recurrence of ACC was more common than distant metastasis. 2 The presence of ACC basement membrane and the degree of its positive expression are related to its type. The positive degree is the highest in the sieve type, followed by the tubular type, and the worst in the solid type. In addition, cases with metastasis or (and) recurrence were found to have low positive expression in the screen-type ACC. Of the 4 basement membrane proteins, the expression of fibronectin was poor in all types of ACC. Conclusion :1 The positive expression of basal membrane protein is negatively correlated with the degree of malignancy of ACC. Basement membrane protein can be used as a basis for evaluating the prognosis of patients. 2 Among the substances involved in the formation of the basement membrane, the basement membrane protein may be the main substance for adhesion between the tumor parenchymal cells and the basement membrane collagen.