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目的探讨妊娠晚期孕妇血清同型半胱氨酸(Hcy)水平与妊娠高血压综合征的相关性。方法在Beckman AU-5400全自动生化仪上采用循环酶法测定39例妊娠高血压妇女(妊高征组),平均年龄(27.9±4.3)岁,平均孕周(36.1±2.4)周;40例正常孕期妇女(正常妊娠组),平均年龄(26.8±5.1)岁,平均孕周(35.5±2.1)周;40例正常孕龄妇女(对照组),平均年龄(25.9±5.3)岁,平均孕周(35.9±2.8)周的血清Hcy含量。3组年龄、孕期比较差异无统计学意义(P>0.05)。结果妊高征组血清Hcy水平(2.8±4.1)μmol/L与正常妊娠组血清Hcy水平(6.9±3.3)μmol/L比较,差异有统计学意义(P<0.05);而与对照组血清Hcy水平(11.9±5.2)μmol/L比较,差异没有统计学意义(P>0.05)。结论测定妊娠期孕妇血清Hcy水平对早期发现和诊断妊娠高血压的发生有重要的意义。
Objective To investigate the relationship between serum homocysteine (Hcy) levels and pregnancy-induced hypertension in the third trimester of pregnancy. Methods The circulating enzyme method was used to measure 39 pregnant women with gestational hypertension (PIH) with the mean age of (27.9 ± 4.3) years and average gestational age (36.1 ± 2.4) weeks on Beckman AU-5400 automatic biochemical analyzer. The average gestational age was (26.8 ± 5.1) years, average gestational age (35.5 ± 2.1) weeks in 40 normal pregnant women (control group), mean age (25.9 ± 5.3) years, average pregnancy rate Week (35.9 ± 2.8) weeks of serum Hcy levels. There was no significant difference between the three groups in age and pregnancy (P> 0.05). Results The serum Hcy level in PIH group was (2.8 ± 4.1) μmol / L compared with that in normal pregnancy group (6.9 ± 3.3) μmol / L, with significant difference (P <0.05) (11.9 ± 5.2) μmol / L, the difference was not statistically significant (P> 0.05). Conclusion The determination of serum Hcy levels in pregnant women during pregnancy is of great significance for the early detection and diagnosis of pregnancy-induced hypertension.