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目的:观察食管胃底静脉曲张出血患者应用垂体后叶素与奥曲肽序惯疗法的有效性。方法:80例患者随机分为治疗组40例,对照组40例,治疗组先给予垂体后叶素0.2~0.4 U/min静脉滴注,出血控制后垂体后叶素每12 h减少0.1 U/min,3 d后改为奥曲肽50μg静脉推注,后以50μg/h的速度持续静脉滴注,连用3 d。对照组单用奥曲肽方法同治疗组共6 d。结果:治疗组总有效率92.5%,平均止血时间(5.11±4)d;对照组有效率72.5%,平均止血时间(7.14±5)d,治疗组优于对照组(P<0.05)。结论:垂体后叶素与奥曲肽序贯疗法治疗食管胃底静脉曲张优于单用奥曲肽。
Objective: To observe the efficacy of pituitrin and octreotide sequential therapy in patients with esophageal variceal bleeding. Methods: Eighty patients were randomly divided into treatment group (n = 40) and control group (n = 40). The treatment group was given intravenous drip of vasopressin 0.2-0.4 U / min. After the bleeding control, vasopressin decreased by 0.1 U / min, 3 d after octreotide 50μg intravenous injection, continuous infusion of 50μg / h speed, once every 3 d. The control group alone octreotide method with the treatment group for 6 d. Results: The total effective rate was 92.5% in the treatment group and the mean hemostasis time was 5.11 ± 4 days. The effective rate in the control group was 72.5% and the average hemostasis time was 7.14 ± 5 days. The treatment group was superior to the control group (P <0.05). Conclusion: Sequential treatment with pituitrin and octreotide is superior to octreotide alone in the treatment of esophageal varices.