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目的探讨胸腔积液端粒酶活性水平对良恶性胸腔积液鉴别诊断的价值。方法用聚合酶链反应 -酶联免疫吸附分析法分别检测3 6例结核性胸腔积液和 3 6例恶性胸腔积液患者的胸液。结果结核性胸腔积液中端粒酶阳性 1例 (2 .8% ) ,恶性胸腔积液中阳性 3 2例(88.9% ) ;灵敏度为 0 .89,特异度为 0 .97。结论测定胸腔积液端粒酶活性水平是鉴别良恶性胸腔积液的重要方法之一。
Objective To investigate the diagnostic value of telomerase activity in benign and malignant pleural effusion. Methods Polymerase chain reaction-enzyme-linked immunosorbent assay was used to detect pleural effusion in 36 patients with tuberculous pleural effusion and 36 with malignant pleural effusion. Results The positive rate of telomerase activity in tuberculous pleural effusion was 1 case (2.8%), and the positive rate was 32.2% (88.9%) in malignant pleural effusion. The sensitivity was 0.89 and the specificity was 0.97. Conclusion The determination of telomerase activity in pleural effusion is one of the important methods to distinguish benign and malignant pleural effusions.