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目的探讨PCT、hs-CRP及WBC联合检测在诊断小儿细菌性肺炎中的临床价值。方法选择62例细菌性肺炎患儿分别计算PCT、hs-CRP及WBC诊断小儿细菌性肺炎的灵敏度、特异度、阳性预测值、阴性预测值及约登指数,并通过Logistic回归和ROC曲线分析3个指标单独和联合检测对小儿细菌性肺炎的诊断价值。结果 PCT诊断细菌性肺炎的灵敏度为88.71%,特异度为92.50%,阳性预测值为94.83%,阴性预测值为84.09%,约登指数为0.79;应用Logistic回归分析,PCT对细菌性肺炎的诊断效能明显大于hs-CRP和WBC;PCT、hs-CRP、WBC单独及联合诊断细菌性肺炎时AUC分别为0.898、0.658、0.653和0.902,3个指标联合检测较单独诊断细菌性肺炎的AUC大。结论 PCT对小儿细菌性肺炎诊断有较高的灵敏度、特异度和诊断效能,PCT、hs-CRP及WBC联合检测对小儿细菌性肺炎有更好的诊断价值。
Objective To investigate the clinical value of combined detection of PCT, hs-CRP and WBC in the diagnosis of bacterial pneumonia in children. Methods The sensitivity, specificity, positive predictive value, negative predictive value and Youden index of PCT, hs-CRP and WBC were calculated in 62 children with bacterial pneumonia and analyzed by Logistic regression and ROC curve analysis. Diagnostic value of single index and combined test in children with bacterial pneumonia. Results The sensitivity, specificity and accuracy of PCT diagnosis of bacterial pneumonia were 88.71%, 92.50%, 94.83%, 84.09%, respectively. The Youden index was 0.79. Using Logistic regression analysis, the PCT diagnosis of bacterial pneumonia The AUC of PCT, hs-CRP and WBC alone and in combination in the diagnosis of bacterial pneumonia were 0.898, 0.658, 0.653 and 0.902, respectively. The combined detection of A, B, C and D was more significant than the diagnosis of bacterial pneumonia alone. Conclusion PCT has high sensitivity, specificity and diagnostic efficacy in the diagnosis of bacterial pneumonia in children. Combined detection of PCT, hs-CRP and WBC has better diagnostic value in children with bacterial pneumonia.