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目的对成人幽门螺杆菌(Hp)感染的慢性特发性血小板减少性紫癜(ITP)患者进行Hp根治,评估其对血小板的影响。方法对30例ITP患者采用前瞻性对照研究,其中19例Hp阳性的患者接受1周三联药物根治,Hp阳性的患者在第0、第2、第4、第12、第24周复查血小板(Plt)计数。结果通过三联治疗HP阳性的患者有94.7%(18/19)根治;58.8%(10/17)Hp根治的患者显示ITP治疗有效。结论对于中国人群来说,轻中度的慢性ITP患者治疗应包括检测Hp及考虑根治Hp感染。
Objective To evaluate the effect of Hp on platelet in patients with chronic idiopathic thrombocytopenic purpura (ITP) infected with Helicobacter pylori (Hp). Methods Thirty patients with ITP were prospectively controlled. Nineteen Hp-positive patients received one-week triple drug therapy. Hp-positive patients underwent repeat thrombolysis at the 0, 2, 4, 12, )count. Results 94.7% (18/19) of the patients were treated with triple therapy of HP, and 58.8% (10/17) of patients treated with Hp showed that ITP was effective. Conclusions For the Chinese population, mild to moderate treatment of chronic ITP patients should include the detection of Hp and consider radical Hp infection.