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大鼠胸部照射γ射线20Gy,照射后观察支气管肺泡灌洗液(BALF)中蛋白质含量、细胞总数和分类及巨噬细胞存活率,肺指数及肺组织纤溶活力,并做了大体解剖和组织学检查。结果为:照射后2周开始BALF中蛋白质含量、细胞总数和中性粒细胞即明显增多,照射后1——2个月持续处于高水平,高峰在1.5─2个月,照射后3─4个月有所下降,肺指数有相应变化;肺组织纤溶活力则相反,从照射后2周开始持续下降,至照射后2个月已降至最低,接近于零。形态学观察也见到有早期肺水肿和晚期肺萎缩等变化。由上结果可见,大鼠胸部照射后的早期主要为渗出性病变和纤溶活力的降低。文中讨论了照射后血管内皮细胞的损伤在放射性肺损伤发病中的作用。
Rats were irradiated with γ-rays 20Gy, and the protein content, cell number and classification, the survival rate of macrophages, lung index and lung fibrinolytic activity in bronchoalveolar lavage fluid (BALF) were observed. The gross anatomy and organization School inspection. The results showed that protein content in BALF began to increase at 2 weeks after irradiation, and the total number of cells and neutrophils increased significantly. The level of BALF remained high for 1-2 months after irradiation, with a peak at 1.5 to 2 months. After irradiation, ──────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────────── Morphological observation also saw changes such as early pulmonary edema and advanced lung atrophy. From the above results, the early chest after irradiation mainly exudative lesions and fibrinolytic activity decreased. The article discusses the role of vascular endothelial cell injury in the pathogenesis of radiation-induced lung injury after irradiation.