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美国Walls等于1980年曾报道过甲氰咪胍引起周围神经病变最初的几个例子.法国也有一例报道.作者也见到一例,报道一例如下:61岁男性病人,于1986年2月26日因急性肾盂肾炎而住院.入院时,神经检查正常.以阿莫西林及庆大霉素治疗十天而感染得到控制.3月份于纤维胃镜下发现轻度胃溃疡后每天以800毫克甲氰咪胍口服治疗七天后病人诉述双侧下肢弥漫性疼痛和跨阈步态.检查发现双侧膝关节以下各类感觉减退,膝反射和跟腱反射消失.CSF正常,以后2个月内也正常.肌电图检查显示为神经原损害,下肢的近、远端肌肉于休息时肌力无异常.运动神经传导速度、远端的潜伏期与F波的潜伏期均正常.腓外神经的感觉电位减低,感觉传导速度接近正常(38米/秒).肌皮神经活检显示神经束膜小静脉的微血管炎.检查除了感染引起的一过性炎性综合征外证明无全身疾患.血常规、肾功能、肝功能、HBs抗原、血清免疫电泳、尿蛋白、冷球蛋白血症、血清补体、抗
The United States Walls equal reported in 1980, cimetidine caused peripheral neuropathy in the first few cases .France also has a case of the report also see an example of a report is as follows: 61-year-old male patient, on February 26, 1986 due to Acute pyelonephritis and hospitalization .Nursing, the nerve examination was normal .In amoxicillin and gentamicin for ten days and infection was controlled.March gastroscopy in March found mild gastric ulcer daily with 800 mg of cimetidine After seven days of oral treatment, the patient complained of diffuse pain and cross-gait of bilateral lower extremities, and found that the following types of sensations of knee below were diminished, knee reflex and Achilles tendon reflex disappeared, CSF was normal and normal within 2 months afterwards Electrocardiogram showed neuronal damage, lower extremity proximal and distal muscles at rest muscle strength without abnormal motor nerve conduction velocity, distal latency and F wave latency were normal.The sensory The conduction velocity was close to normal (38 m / s) .Miceroneal nerve biopsy showed microvascular inflammation of the pericardial venules. Examination showed no systemic disease other than the transient inflammatory syndrome caused by infection. Blood, kidney function Liver function, HBs antigen, serum immunoglobulin electrophoresis, urine protein, cryoglobulinemia, serum complement, anti-