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Background: To determine whether -148 C/T fibrinogen gene promoter polymorp hism increases stroke risk by modifying the fibrinogen level. Design: A case-c ontrol study of patients with first ever ischaemic stroke, confirmed by computed tomography. Methods: Venous blood samples were collected for fibrinogen and rou tine coagulation tests one week after the stroke, and after three months in abou t half the patients. Population controls were age and sex matched. -148 G/T fi brinogen polymorphism was determinedly polymerase chain reaction followed by dig estion with restriction enzymes HindIII/Alul. Results: There were 124 patients a nd 125 controls, mean age 56 years (range 18 to 75); 34 patients (27% ) and 41 controls (33% ) were heterozygous for -148 C/T fibrinogen polymorphism, six p atients (5% ) and five controls (4% ) had the T/T genotype. The odds ratio of ischaemic stroke associated with CC homozygotes v T carriers was 0.8 (95% conf idence interval, 0.5 to 1.4). Relative risk for ischaemic stroke associated with fibrinogen levels in the highest quartile was 3.9 (1.9 to 8;4) at one week, dec reasing to 1.4 (0.6 to 3.3) at three months. Conclusions: -148 C/T fibrinogen gene polymorphism was not a strong risk factor for ischaemic stroke. High fibrin ogen levels early after acute stroke probably represent an acute phase response.
Background: To determine whether -148 C / T fibrinogen gene promoter polymorp hism increases stroke risk by modifying the fibrinogen level. Design: A case-c ontrol study of patients with first ever ischaemic stroke, confirmed by computed tomography. Methods: Venous blood samples were collected for fibrinogen and rou tine coagulation tests one week after the stroke, and after three months in abou t half the patients. Population controls were age and sex matched. -148 G / T fi brinogen polymorphism was determinedly polymerase chain reaction followed by dig 34 patients (27%) and 41 controls (33%) were heterozygous for-148 C / The odds ratio of ischaemic stroke associated with CC homozygotes v T carriers was 0.8 (95% conf idence interval, 0.5 to 1.4 (5%) and five controls (4%) had the T / T genotype. ) Relative risk for ischaemic stroke associated with fibrinogen levels in the highest quartile was 3.9 (1.9 to 8; 4) at one week, dec reasing to 1.4 (0.6 to 3.3) at three months. Conclusions: -148 C / T fibrinogen gene polymorphism was not strong risk factor for ischaemic stroke. High fibrin ogen levels early after acute stroke may represent an acute phase response.