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目的 检测人表皮生长因子受体 (HER)及其基因 (erbB)家族在非癌肺组织和肺癌组织中的表达 ,探讨HER过度表达与肺癌临床病理的关系。方法 采用免疫组化的方法分别检测 2 0例非癌肺组织及有随访资料的 70例肺癌 (4 3例鳞癌和 2 7例腺癌 )组织中HER的表达。结果 HER在非癌肺组织存在阳性表达 (+) ;肺癌中存在HER1、HER2 、HER4 的过度表达 ,该过度表达与肺癌病理类型、分化程度不相关 ,而与肺癌淋巴结转移、TNM分期、患者术后生存率相关。结论 erbB1,erbB2 ,erbB4 是晚期肺癌生长的调控基因 ,干预其过度表达可能是治疗晚期肺癌的有效方法。
Objective To detect the expression of human epidermal growth factor receptor (HER) and its gene (erbB) family in non-cancerous lung tissues and lung cancer tissues and to explore the relationship between overexpression of HER and the clinicopathological features of lung cancer. Methods Immunohistochemical method was used to detect the expression of HER in 70 lung cancer tissues (43 squamous cell carcinoma and 27 adenocarcinoma) with non-cancerous lung tissue and follow-up data. Results There was a positive expression of HER in non-cancerous lung tissues (+). There was overexpression of HER1, HER2 and HER4 in lung cancer. The overexpression of HER1 was not related to the pathological type and differentiation of lung cancer, but was associated with lymph node metastasis, TNM staging, Post-survival rate related. Conclusions erbB1, erbB2 and erbB4 are the regulatory genes of advanced lung cancer. Interference of overexpression may be an effective method for the treatment of advanced lung cancer.