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我院于1988年3月至1991年8月联合应用多巴酚丁胺(dobutamine)和酚妥拉明治疗顽固性心衰28例,疗效显著,无明显副作用,现报道如下。材料与方法本组28例均为1988年3月至91年8月我院内科收治的顽固性心衰病人,其中男11例,女17例;年龄15～71岁,平均37.9±15.3岁。28例中风心病7例、肺心病5例、冠心病12例(包括急性心肌梗塞1例、陈旧性心肌梗塞3例)、高心病3例、扩张型心肌病1例。发生心衰时间最长10年,最短3天,平均2.2±1.1年。心功能分级按纽约心脏病协会(NYHA)标准,均属4级。采用多巴酚丁胺40mg及酚妥拉明10～20mg加入5～10％葡萄糖250ml中,3小时左右滴完,平均多巴酚丁胺约4.8μg/kg/min,酚妥拉明约1.2～2μg,/kg/min,每天一次,疗程不定。血压低于10.6/6.7kPa不
In our hospital in March 1988 to August 1991, combination of dobutamine and phentolamine treatment of refractory heart failure in 28 cases, the effect was significant, no obvious side effects, are reported below. Materials and Methods The group of 28 patients were admitted to our hospital from March 1988 to August 1991 refractory heart failure patients, including 11 males and 17 females; aged 15 to 71 years, an average of 37.9 ± 15.3 years. 28 cases of stroke in 7 cases, 5 cases of cor pulmonale, coronary heart disease in 12 cases (including 1 case of acute myocardial infarction, 3 cases of old myocardial infarction), 3 cases of high heart disease, dilated cardiomyopathy in 1 case. Heart failure occurred for up to 10 years, the shortest 3 days, an average of 2.2 ± 1.1 years. Heart function grading by New York Heart Association (NYHA) standards, are four. Using dobutamine 40mg and phentolamine 10 ~ 20mg added 5 ~ 10% glucose 250ml, drip finished about 3 hours, average dobutamine about 4.8μg / kg / min, phentolamine about 1.2 ~ 2μg, / kg / min, once daily, undetermined course of treatment. No blood pressure below 10.6 / 6.7kPa