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肥胖可引起胰岛素抵抗和2型糖尿病,但其确切机制尚不清楚。新近发现小鼠白色脂肪组织可特异分泌一种富含半胱氨酸的蛋白质,被认为是小鼠肥胖与胰岛素抵抗的重要中间环节,称为胰岛素抵抗因子（resistin）。小鼠resistin的基因定位于第8对染色体上,resistin仅在小鼠的白色脂肪组织中有高度表达,属于富含半胱氨酸的分泌型蛋白RELMs（resistin-like molecules）家族,其水平在由3T3-L1细胞向成熟脂肪细胞转化的过程中显著增高,并与胰岛素抵抗有紧密的联系。地塞米松能促进resistin基因表达,而异丙肾上腺素与肿瘤坏死因子α则能抑制其表达。在人类脂肪细胞表达的resistin同源物,基因定位在第19对染色体,其组织分布与作用尚有待进一步研究。本文介绍了胰岛素抵抗因resistin的发现过程、其家族特点、与胰岛素抵抗及其调节因子的关系等。
Obesity can cause insulin resistance and type 2 diabetes, but the exact mechanism is not clear. Recently, mouse white adipose tissue can specifically secreted a cysteine-rich protein, which is considered as an important intermediate link between obesity and insulin resistance in mice and is called as resistin. The mouse resistin gene is located on chromosome 8 and resistin is highly expressed in mouse white adipose tissue and belongs to the cysteine-rich resistin-like molecules family, The 3T3-L1 cells are significantly increased during their transformation into mature adipocytes and have a close relationship with insulin resistance. Dexamethasone can promote resistin gene expression, and isoproterenol and tumor necrosis factor alpha can inhibit its expression. Resistin homologues, which are expressed in human adipocytes, are located on chromosome 19 and their distribution and function remain to be further studied. This article describes the discovery of insulin resistance due to resistin, its family characteristics, and insulin resistance and its regulatory factors.