【摘 要】
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Dear Editor,rnTransmembrane proteins with multiple transmembrane domains are rarely found inside nuclei for good reason.To achieve intranuclear localization,the hypothetical transmembrane protein must first be extracted from its host membrane and the mult
【机 构】
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State Key Laboratory of Membrane Biology,Tsinghua-Peking University Joint Center for Life Sciences,S
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Dear Editor,rnTransmembrane proteins with multiple transmembrane domains are rarely found inside nuclei for good reason.To achieve intranuclear localization,the hypothetical transmembrane protein must first be extracted from its host membrane and the multiple hydrophobic transmembrane domains must be protected from the hydrophilic environment of the cytoplasm to maintain the proper conformation of the protein.Mechanistically,this poses consider-able challenges.
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