【摘 要】
：
Dear Editor,rnTargeted protein degradation (TPD) represents a promising research field that has quickly attracted attention and efforts from both academia and pharmaceutical industry.TPD technology uses small molecules to induce the degradation of target
【机 构】
：
MOE Key Laboratory of Protein Sciences,School of Pharmaceutical Sciences,MOE Key Laboratory of Bioor
论文部分内容阅读
Dear Editor,rnTargeted protein degradation (TPD) represents a promising research field that has quickly attracted attention and efforts from both academia and pharmaceutical industry.TPD technology uses small molecules to induce the degradation of target proteins by harnessing the ubiquitin-proteasome system.PROTAC (PROteo-lysis Targeting Chimeras)1-3 and MG (Molecular Glue)4,5 are two major modes of TPD.PROTACs comprise three parts,including a ligand for binding a target protein,another ligand for recruiting an E3 ligase,and a linker,which helps anchoring the target protein to the E3 ubiquitin ligase,to promote its ubiquitination and subsequent proteasomal degradation.Similar to PROTACs,MGs can also cause ubiquitination and degradation of a target protein.
其他文献
True-seed potato has been the holy grail of potato breeding for decades;genetic improvement,notably resistance breeding,has lagged behind in this vegetatively propagated,polyploid staple crop.A recent study by Zhang et al.in Cell shows how genomics can gr
Sphingosine-1-phosphate (S1P) is an important bioactive lipid molecule in cell membrane metabolism and binds to G protein-coupled S1P receptors (S1PRs) to regulate embryonic development,physiological homeostasis,and pathogenic processes in various organs.
Coronavirus disease 2019 (COVID-19),caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),is the ongoing global pandemic that poses substantial challenges to public health worldwide.A subset of COVID-19 patients experience systemic inflam
The infusion of coronavirus disease 2019 (COVID-19) patients with mesenchymal stem cells (MSCs) potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled (29 patients/grou
Telomerase,a multi-subunit ribonucleoprotein complex,is a unique reverse transcriptase that catalyzes the processive addition of a repeat sequence to extend the telomere end using a short fragment of its own RNA component as the template.Despite recent st
Circadian rhythms play an important role in balancing innate and adaptive immune responses.In a recent study in Cell Research,Zhang et al.studied the immunological response in humans to an inactivated SARS-CoV-2 vaccine administered at two different times
Intestinal stem cell (ISC) differentiation is regulated precisely by a niche in the crypt,where lymphocytes may interact with stem and transient amplifying (TA) cells.However,whether and how lymphocyte-stem/TA cell contact affects ISC differentiation is l
Dear Editor,rnThe genotype imputation is an efficient and pivotal approach to estimate the unobserved genotypes in the genomic data from the single nucleotide polymorphism (SNP) genotyping arrays or whole-genome sequencing (WGS).The fine mapping of varian
Increasing numbers of SARS-CoV-2-positive (SARS-CoV-2pos) subjects are detected at silent SARS-CoV-2 infection stage (SSIS).Yet,SSIS represents a poorly examined time-window wherein unknown immunity patterns may contribute to the fate determination toward
Dear Editor,rnThe ten mammalian Frizzleds (FZD1-10) belong to the class F of G protein-coupled receptors (GPCRs) and mediate WNT signaling through interaction with transducer proteins including Dishev-elled (DVL) or heterotrimeric G proteins.1 Their invol