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目的:在传统使用盐酸小檗碱抑制乳腺癌细胞生长的基础上,以中医扶正祛邪理论为指导,联合使用扶正祛毒方及盐酸小檗碱治疗乳腺癌患者,以观察其对乳腺癌细胞生长的抑制作用,并进行讨论,以求为临床使用中西药联合治疗乳腺癌提供新思路、新方法。方法:选取2014年3月—2015年12月在医院进行治疗的乳腺癌患者59例,将其随机按数字表法分为对照组和观察组,对照组患者(29例)给予盐酸小檗碱进行治疗,观察组(30例)患者给予扶正祛毒方联合盐酸小檗碱进行治疗,观察比较两组患者的治疗效果。结果:治疗后,相比于对照组,观察组患者总有效率明显较高,统计差异具有明显的意义(χ2=4.584 4,P<0.05);治疗前,相比于对照组,观察组患者的肿瘤坏死因子、白细胞介素-12水平无意义(P>0.05)。治疗后,相比于对照组,观察组患者的肿瘤坏死因子、白细胞介素-12水平相对优于对照组,统计差异有意义(P<0.05)。结论:在中医扶正祛邪理论的指导下,采用扶正祛毒方联合盐酸小檗碱治疗乳腺癌优于单纯使用盐酸小檗碱,能够更加有效地抑制乳腺癌细胞生长,促进癌细胞凋亡,减少乳腺癌患者的痛苦,提高其生活质量,是中西药联合抑制乳腺癌细胞生长的有效方法之一,值得推广。
OBJECTIVE: Based on the traditional use of berberine hydrochloride to inhibit the growth of breast cancer cells, guided by the theory of Chinese medicine strengthening and removing evil, combined with the treatment of Fuzheng Qudu and berberine in patients with breast cancer to observe its effect on breast cancer cells Growth inhibition, and discussed in order to provide new ideas, new methods for the clinical use of Chinese and Western medicine combined treatment of breast cancer. Methods: 59 patients with breast cancer who were treated in the hospital from March 2014 to December 2015 were randomly divided into control group and observation group according to the digital table method. The control group (29 cases) received berberine hydrochloride The patients in the observation group (30 cases) were given Fuzheng Qudu Decoction combined with berberine hydrochloride for treatment. The therapeutic effect was observed and compared between the two groups. Results: Compared with the control group, the total effective rate was significantly higher in the observation group after treatment, with statistical significance (χ2 = 4.584 4, P <0.05). Before treatment, the patients in the observation group Of tumor necrosis factor, interleukin-12 levels of no significance (P> 0.05). Compared with the control group, the levels of tumor necrosis factor and interleukin-12 in the observation group were better than those in the control group after treatment, and the difference was statistically significant (P <0.05). Conclusion: Under the guidance of the theory of strengthening the body and removing pathogenic factors, using Fuzheng Qidu decoction combined with berberine hydrochloride to treat breast cancer is superior to using berberine alone, which can inhibit the growth of breast cancer cells more effectively and promote the apoptosis of cancer cells. Reduce the pain of breast cancer patients and improve their quality of life, is an effective way to inhibit the growth of breast cancer cells, which is worth promoting.