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Bulk Cu/V multilayers simultaneously possess high strength and excellent radiation resistance thanks to their high density of interfaces.Irradiation-induced atomic mixing of Cu/V multilayers has been less investigated.Here,we investigate the ion irradiation of bulk Cu/V multilayers exposed to H+2 or He+ ions at 350℃.The microstructure and elemental distribution are investigated by transmission electron microscopy and energy dispersive x-ray spectroscopy.Facetted bubbles and atomic mixing are observed after ion irradiation.The possible mechanisms of irradiation-induced atomic mixing are discussed.