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目的:研究不同煎煮方法黄连阿胶汤对口腔溃疡模型大鼠作用的差异。方法:将SD大鼠分为空白对照组、口腔溃疡模型组、口炎清组、黄连阿胶汤传统煎煮、机械常压、机械高压组,选用甲状腺和苯酚综合造模阴虚型口腔溃疡,取大鼠全血分离血清,采用酶免法测定三碘甲状腺原氨酸(T3)、甲状腺素(T4)、肿瘤坏死因子(TNF-α)和血管内皮生长因子(VEGF)含量。结果:黄连阿胶汤模型组与对照组之间T3、T4具有显著升高(P<0.01);TNF-α、VEGF具有显著性差异(P<0.01);传统煎煮组、机械常压组、机械高压组之间T3、T4、TNF-α、VEGF含量没有显著性差异(P>0.05)。结论:黄连阿胶汤对阴虚口腔溃疡大鼠有治疗作用,但不同煎煮方法样品治疗作用无显著差异。
Objective: To study the effects of different decoctions of berberine gelatin soup on oral ulcer model rats. Methods: SD rats were divided into blank control group, oral ulcer model group, Kou Yan Qing group, Huanglian gelatin soup traditional decoction, mechanical pressure, mechanical high pressure group, the selection of thyroid and phenol comprehensive modeling of deficiency of oral ulcer, Serum samples were separated from whole blood of rats and the contents of T3, T4, TNF-α and VEGF were determined by enzyme immunoassay. Results: The levels of T3 and T4 in the model group and the control group were significantly increased (P <0.01), TNF-α and VEGF were significantly different (P <0.01) There was no significant difference in the contents of T3, T4, TNF-α and VEGF between the mechanical high-pressure group (P> 0.05). Conclusion: Huanglian donkey-hide gelatin soup has a therapeutic effect on rats with oral ulcer, but there is no significant difference in the therapeutic effects between different decoction samples.