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本文对选择性β_2受体激动剂之一,特布他林的药物动力学、药效动力学及其临床药理学资料,作了较为详细和系统的介绍,也介绍了国内外治疗学倾向。迄今为止,该药已在100多个国家使用。由于哮喘治疗药的选择性差而引起心血管的严重副作用,引起了医学界的关注。有人认为哮喘的病死率近年有上升趋势,这与滥用止喘药有关。许多国家已将选择性β_2激动剂作为治疗哮喘的首选药,国内对此问题亦在日趋引起重视。
In this paper, the pharmacokinetics, pharmacodynamics and clinical pharmacology data of one of the selective β_2 receptor agonists and terbutaline were introduced in detail and systematically. The tendency of therapies at home and abroad was also introduced. To date, the drug has been used in more than 100 countries. Due to the poor selectivity of asthma treatment drugs cause serious cardiovascular side effects, aroused the medical community’s attention. Some people think that the mortality rate of asthma has been on the rise in recent years, which is related to the abuse of antiasthmatic drugs. In many countries, selective β 2 agonists have been the first choice for the treatment of asthma. At home, this problem is also attracting more and more attention.