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目的：研究反复脑缺血大脑皮质白三烯（ＬＴＣ４）、环腺苷酸（ｃＡＭＰ）和氧自由基（ＯＦＲ）的代谢变化与神经元损伤的关系。方法：对比观察大鼠反复性与单次性脑缺血大脑皮质ＬＴＣ４、ｃＡＭＰ、超氧化物歧化酶（ＳＯＤ）和丙二醛（ＭＤＡ）的含量变化及相应的病理改变。结果：反复缺血及再灌流早期ＬＴＣ１、ｃＡＭＰ的含量明显升高，ＳＯＤ活性显著降低，ＭＤＡ延迟性持续显著增高，皮质神经元损害显著重于单次缺血组。结论：ＬＴＣ４、ｃＡＭＰ和 ＯＦＲ均参与了反复缺血性脑损害的病理机制，可能与 Ｃａ＋＋介导的花生四烯酸（ＡＡ）瀑布效应有关。
OBJECTIVE: To study the relationship between neuronal injury and the metabolic changes of cerebral cortex leukotriene (LTC4), cyclic adenosine (cAMP) and oxygen free radical (OFR) after repeated cerebral ischemia. Methods: The levels of LTC4, cAMP, SOD and MDA in rats with recurrent and single cerebral ischemia were compared and their pathological changes were observed. Results: The levels of cAMP, LTC1 and SOD in the early stage of repeated ischemia and reperfusion were significantly increased, the activity of SOD was significantly decreased, the delay of MDA was significantly increased, and the damage of cortical neurons was significantly heavier than that of the single ischemia group. CONCLUSION: Both LTC4, cAMP and OFR are involved in the pathogenesis of recurrent ischemic brain damage, which may be related to Ca ++ mediated arachidonic acid (AA) waterfall effect.