Genetic and epigenetic biomarkers for diagnosis, prognosis and treatment of colorectal cancer

• 作 者: Fabio Coppedè Angela Lopo
• 机 构: DepartmentofTranslationalResearchandNewTechnologiesinMedicineandSurgery,IstitutoToscanoTumori（ITT）,D
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2014年4期
• 关键词: COLORECTAL cancer GENETIC biomarkers EPIGENETIC bi Colorectal cancer Genetic bi
• 基金项目: Supported by T Istituto Toscano Tumori(ITT)No.Prot.AOOGRT/325424/Q.80.110 16/12/2009； ‘‘Correlation among epigenetic； environmental and genetic factors in colorectal carcinoma’’

Colorectal cancer(CRC)is one of the most common cancer worldwide and results from the accumulation of mutations and epimutations in colonic mucosa cells ultimately leading to cell proliferation and metastasis.Unfortunately,CRC prognosis is still poor and