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目的:评价甲硝唑与尼尔雌醇联用对萎缩性阴道炎患者的临床疗效。方法:选取2014年1月—2015年12月诊治的萎缩性阴道炎患者86例,将其随机分为甲组和乙组,每组43例;甲组患者给予甲硝唑与尼尔雌醇联用治疗,乙组患者给予甲硝唑治疗,比较两组患者治疗后的总有效率和治疗前后阴道pH测得值,以及不良反应的发生率。结果:甲组患者治疗后的总有效率高于乙组(P<0.05),不良反应的发生率低于乙组(P<0.05);治疗后两组患者的阴道pH测得值均低于治疗前(P<0.05);甲组患者治疗后阴道pH测得值低于乙组(P<0.05)。结论:甲硝唑与尼尔雌醇联用于治疗萎缩性阴道炎患者的临床疗效优于单用甲硝唑。
Objective: To evaluate the clinical efficacy of metronidazole combined with nilestriol in patients with atrophic vaginitis. Methods: Totally 86 patients with atrophic vaginitis diagnosed and treated from January 2014 to December 2015 were selected and randomly divided into group A and group B (43 cases in each group). Patients in group A were treated with metronidazole and nilestriol Combination therapy, patients in group B were treated with metronidazole, the total effective rate after treatment and vaginal pH measured before and after treatment were compared, as well as the incidence of adverse reactions. Results: The total effective rate after treatment in Group A was higher than that in Group B (P <0.05), and the incidence of adverse reactions was lower than that in Group B (P <0.05). The vaginal pH values of both groups were lower than Before treatment (P <0.05), the vaginal pH of group A was lower than that of group B after treatment (P <0.05). Conclusion: Metronidazole combined with nilestriol is superior to metronidazole in the treatment of atrophic vaginitis.