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目的:评价加替沙星与奥硝唑联用对急性下尿路出血患者血清炎症因子的影响及临床疗效。方法:选取2015年1月—2016年1月间诊治的急性下尿路出血患者145例,按照就诊先后顺序分为将其分为A组49例、B组48例和C组48例;A组患者仅给予加替沙星注射液治疗,B组患者仅给予口服奥硝唑治疗;C组患者均给予加替沙星与奥硝唑联用治疗,评价3组患者治疗后的血清炎症因子和变化情况和治疗后的总有效率。结果:C组患者治疗后CRP水平、白细胞计数、血沉及PCT水平明显低于A、B两组(P<0.05);A组与B组经比较其差异无统计学意义(P>0.05);C组患者治疗后的总有效率明显高于A组和B组(P<0.05)。结论:加替沙星注射液与奥硝唑联用治疗急性下尿路出血患者,对改善其血清炎症因子水平和临床疗效果具有重要意义。
Objective: To evaluate the effect of gatifloxacin combined with ornidazole on serum inflammatory factors in patients with acute lower urinary tract hemorrhage and its clinical efficacy. Methods: A total of 145 patients with acute lower urinary tract hemorrhage who were diagnosed and treated between January 2015 and January 2016 were selected and divided into 49 cases in group A, 48 cases in group B and 48 cases in group C according to the order of their visits. A Group G was given only gatifloxacin injection, patients in group B were treated with oral ornidazole only; patients in group C were treated with gatifloxacin and ornidazole in combination to evaluate the serum levels of inflammatory cytokines And changes and the total effective rate after treatment. Results: The CRP level, white blood cell count, erythrocyte sedimentation rate and PCT level in group C were significantly lower than those in group A and B (P <0.05). There was no significant difference between group A and group B (P> 0.05). The total effective rate after treatment in group C was significantly higher than that in groups A and B (P <0.05). Conclusion: Gatifloxacin injection combined with ornidazole in the treatment of patients with acute lower urinary tract hemorrhage is of great significance in improving the level of serum inflammatory cytokines and clinical efficacy.