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残粒脂蛋白被认为是致动脉粥样硬化的脂蛋白。脂肪细胞分泌的各种促炎脂肪因子在动脉粥样硬化发生、发展的慢性炎症反应中起重要作用。肥胖是冠心病和动脉粥样硬化的一个独立危险因素。残粒脂蛋白通过刺激促炎脂肪因子的释放、诱导前体脂肪细胞向成熟脂肪细胞的成脂分化,从而促进动脉粥样硬化的发生发展。此外,脂肪细胞对残粒脂蛋白代谢的调节也可能影响残粒脂蛋白在体内致动脉粥样硬化作用的强度。
Remnant lipoproteins are considered to be atherogenic lipoproteins. The various proinflammatory adipokines secreted by adipocytes play an important role in the development of chronic inflammatory responses to atherosclerosis. Obesity is an independent risk factor for coronary heart disease and atherosclerosis. Remnant lipoprotein promotes the development of atherosclerosis by stimulating the release of proinflammatory adipokines and inducing the adipogenic differentiation of precursor adipocytes into mature adipocytes. In addition, the regulation by fat cells of the metabolism of remnants of lipoproteins may also influence the intensity of the atherogenic effect of remnants of lipoproteins in vivo.