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目的 探讨2种血清肿瘤标志在乳腺癌手术治疗效果评价、转移复发监测中的应用价值。方法 应用酶联免疫吸收附双抗夹心法测定组织多肽抗原(TPA)和CA15-3。共测定35例健康成人及55例乳腺癌患者,并对其中41例患者进行了手术后随访检测。结果,健康成人组血清TPA为(0.5±O.2)ug/L,CA15-3为(16.1±5.5)×103U/L,乳腺癌患者Ⅰ、Ⅱ、Ⅲ、Ⅳ期2项肿瘤标志均较健康成人组有明显增高,差异有显著意义(P<0.05)。术后和术后转移复发组2种肿瘤标志检测结果与术前差异无显著意义(P>0.05);但2种肿瘤标志在术后组有明显降低,在转移复发组与术前组相比有明显增高。2项联合检测的敏感性为85.4％,特异性为90.9％。结论TPA和CA15-3联合检测对乳腺癌术后疗效监没及判断肿瘤进展有意义。
Objective To investigate the value of two serum tumor markers in the evaluation of surgical treatment of breast cancer and the surveillance of metastasis and recurrence. Methods Tissue polypeptide antigens (TPA) and CA15-3 were determined by ELISA and enzyme-linked immunosorbent assay (ELISA). A total of 35 healthy adults and 55 cases of breast cancer were measured, and 41 patients were followed up after surgery. Results Serum levels of TPA in healthy adults were (0.5 ± 0.2) μg / L and CA15-3 was (16.1 ± 5.5) × 103 U / L, respectively. The tumor markers in stage Ⅰ, Ⅱ, Ⅲ, The healthy adult group was significantly higher, the difference was significant (P <0.05). There was no significant difference between the two tumor markers in postoperative and postoperative metastasis and recurrence group (P> 0.05). However, the two tumor markers in the postoperative group were significantly lower than those in the preoperative group Significantly increased. The sensitivity of the two combined tests was 85.4% with a specificity of 90.9%. Conclusion The combined detection of TPA and CA15-3 has a significant effect on monitoring postoperative efficacy of breast cancer and judging tumor progression.