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目的 研究电化学治疗方法对肝癌化疗栓塞(TAE)后残癌治疗疗效,提高残癌的治疗效果。材料和方法 30例已行肝癌TAE患者,CT或DSA显示仍有较大的活癌灶存在。采用BK-92电化学治疗仪系统,在电视导向下,根据残癌的大小和范围插入铂金针4～16支;通电时间1～2小时,电流100～150mA;电压1～10伏;电量500～1200库伦。术中间隔5～7天,最多者行4次治疗。结果 全部患者均在治疗开始后10～20分钟从负极排出淡黄色气泡,针口出血情况随通电时间延长可形成血痂;术后3天内均出现发热(<38℃),白细胞轻度升高(<10//10~9/L),大便次数增加(<3次/日);治疗结束后1月复查CT发现行针区域均呈直径2～2.5cm圆柱形坏死,肝癌边界和残癌灶均有明显缩小。残癌灶完全缓解(CR)6例,部分缓解(PR)19例,稳定(NR)3例,恶化(PD)2例,有效率PR+CR为83.3％。结论 电化学治疗是对肝癌TAE术后残癌治疗的一个有效的补充方法。
Objective To study the therapeutic effect of electrochemical therapy on residual cancer after chemoembolization (TAE) and to improve the therapeutic effect of residual cancer. Materials and Methods 30 cases of TAE patients with liver cancer, CT or DSA showed that there is still a large live foci exist. Using BK-92 electrochemical treatment system, under the guidance of television, according to the size and scope of residual cancer into the platinum needle 4 to 16; power time of 1 to 2 hours, the current 100 ~ 150mA; voltage of 1 to 10 volts; electricity 500 ~ 1200 Coulomb. Intraoperative interval of 5 to 7 days, up to 4 lines of treatment. Results All patients were excreted with light yellow bubbles from the negative electrode 10 to 20 minutes after the start of treatment. The blood flow of the needle orifice was enhanced with the prolongation of electrification time. Blood was formed within 3 days after operation (<38 ℃) (<10 // 10 ~ 9 / L), and stool frequency increased (<3 times / day). CT examination in January after the end of treatment showed that the needle acreage was 2 ~ 2.5cm in diameter, with cylindrical necrosis, Stoves have significantly reduced. There were 6 cases of complete remission (CR), 19 cases of partial remission (PR), 3 cases of stable (NR) and 2 cases of worsening (PD). The effective rate of PR + CR was 83.3%. Conclusion Electrochemotherapy is an effective supplement to the treatment of residual cancer after TAE of liver cancer.