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用国产利凡诺参照有关标准方法进行小鼠急性、亚急性、蓄积性毒性实验,豚鼠致敏实验及犬亚慢性毒性实验,结果表明:急性毒性实验的LD_(50)(i.v)为(18.94±2.90)mg/kg,属中等毒性物质。动物静脉连续给药(1mg/kg)2～3个月,小鼠亚急性或犬亚慢性毒性实验,均未见任何毒性作用。剂量增至9mg/kg,亦未见犬有毒性表现,仅小鼠肝组织出现轻度变性、细胞局灶性坏死、炎症细胞浸润、枯夫氏细胞增生,其余脏器未见异常。蓄积性实验结果LD_(50)为19.3mg/kg,大于LD_(50),说明利凡诺在小鼠体内无明显蓄积作用。豚鼠腹腔给药无致敏反应。
The results showed that the LD_ (50) (iv) of acute toxicity test was (18.94), with the domestic rivanol referring to the relevant standard methods for acute, subacute and accumulative toxicity test in mice, guinea pig sensitization test and canine subchronic toxicity test ± 2.90) mg / kg, is a moderate toxic substances. Animals intravenous administration (1mg / kg) for 2 to 3 months, mice subacute or sub-chronic canine toxicity test, no toxic effects were seen. Dose increased to 9mg / kg, nor dogs showed toxic manifestations, only mild liver degeneration in mice, focal cell necrosis, inflammatory cell infiltration, cell growth of Khufu’s cells, the other organs were normal. Accumulation of the experimental results LD_ (50) was 19.3mg / kg, greater than LD_ (50), indicating that rivanol no significant accumulation in mice. Guinea pig intraperitoneal administration without sensitization.