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Toll样受体作为一种连接先天性免疫和特异性免疫的桥梁,既在炎症反应、细胞信号转导、细胞凋亡中起重要作用,也是在肿瘤的发生发展中参与免疫调节及免疫逃逸的重要因子.大量临床、基础实验研究表明,TLRs在肺癌、乳腺癌、结肠癌等腺癌中出现异常表达.近年来妇科恶性肿瘤与Toll样受体的关系也越来越受关注,笔者就TLRs与卵巢癌、宫颈癌、子宫内膜癌的研究进展作简要综述.“,”As a connecting bridge between innate immunity and specific immunity,the Toll-like receptors (TLRs) play a significant role in inflammation,cellular signal transduction,and cell apoptosis.TLRs are also essential factors participating in immune regulation and immune escape in the pathogenesis and development of malignant tumors.A large number of clinical and experimental research have shown that the abnormal expression of TLRs can be detected in adenocarcinoma,such as lung cancer,breast cancer and colon caner.In recent years,the relationship between gynecologic malignant tumor and TLRs has received great interest.This article will review and summarize research progress of TLRs in ovarian cancer,cervical cancer,and endometrial neoplasia.