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子痫前期是妊娠期特有的疾病,以妊娠20周后出现高血压和蛋白尿为特征,并伴有全身多脏器损害。目前研究认为,子痫前期-子痫的发病起源于滋养细胞侵袭不足引起的胎盘病理生理改变,进一步导致全身血管内皮细胞损伤,从而引起子痫前期的一系列临床症状。可溶性血管内皮生长因子受体1(sFlt-1)在子痫前期的发生发展过程中起重要作用,干扰滋养细胞侵袭和母体血管重铸过程,参与子痫前期炎症反应和引发母体血管内皮功能障碍。
Preeclampsia is a peculiar disease during pregnancy, characterized by hypertension and proteinuria after 20 weeks gestation, accompanied by systemic multiple organ damage. The current study suggests that the pathogenesis of preeclampsia - eclampsia originated from the placental pathophysiology caused by inadequate trophoblast invasion, further leading to systemic vascular endothelial cell injury, causing a series of clinical symptoms of preeclampsia. Soluble vascular endothelial growth factor receptor 1 (sFlt-1) plays an important role in the development and progression of preeclampsia, interferes with the process of trophoblast invasion and maternal vascular remodeling, participates in preeclampsia and initiates maternal vascular endothelial dysfunction .