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钙通道阻滞剂也称为钙拮抗剂或慢通道阻滞剂。早在18世纪,人们就认识到人体细胞的许多生理功能,包括心肌收缩力,神经冲动的传导,平滑肌收缩和内分泌腺的活性等都与细胞内钙及钙的调节有密切关系。钙通道阻滞剂通过阻止钙离子跨膜内流,抑制细胞内贮存钙释放,降低细胞膜钙通道口数量和敏感性,使细胞内钙离子浓度降低而发挥作用。近年来的临床应用表明,钙通道阻滞剂可用于多种疾病的治疗。现将国外有关儿科临床应用方
Calcium channel blockers are also known as calcium antagonists or slow channel blockers. As early as the 18th century, people realized that many physiological functions of human cells, including myocardial contractility, conduction of nerve impulses, smooth muscle contraction and endocrine gland activity, are closely related to the regulation of intracellular calcium and calcium. Calcium channel blockers play a role in preventing intracellular Ca2 + transmembrane influx, inhibiting intracellular calcium release, reducing the number and sensitivity of cell Ca2 + channels, and decreasing intracellular calcium concentration. In recent years, clinical application shows that calcium channel blockers can be used for the treatment of many diseases. Now abroad for pediatric clinical application side