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甲氰咪胺为组胺H_2受体拮抗剂,药理研究证明组胺作用于H_1、H_2二种受体。引起气管收缩和毛细血管扩张作用的,是由于兴奋H_1受体,并能被一般习用的抗组胺药物所拮抗,增进胃壁细胞酸分泌的H_2受体,其作用不为一般抗组胺药物所消除。经过化学结构改造与筛选,发现了一类H_2受体拮抗剂,在这类药物中,以氰胍基取代硫脲部分而合成的甲氰咪胺,其毒性较轻。体内作用 1.抑制胃酸分泌:甲氰咪胺能减少胃在静止状态(基础胃酸)及为食物、组胺、五肽胃泌素、胰岛素、咖啡因等刺激后胃酸分泌的容量与浓度,其效能优于抗胆硷能
Cimetidine is a histamine H 2 receptor antagonist, and pharmacological studies have shown that histamine acts on both H 1 and H 2 receptors. Caused by tracheal contraction and telangiectasia, is due to the excitement of H 1 receptors, and can be antagonized by the general use of antihistamines, gastric acid secretion of H 2 receptors, and its role is not as antihistamines eliminate. After chemical structure transformation and screening, we found a class of H 2 receptor antagonists. Among these drugs, cyanocarbamides partially substituted with thiourea are less toxic. In vivo 1. Inhibition of gastric acid secretion: Cimetidine can reduce the stomach in resting state (basal gastric acid) and food, histamine, pentagastrin, insulin, caffeine and other gastric acid secretion capacity and concentration stimulation, the Effective than anticholinergic