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急性呼吸衰竭期间,吸气初0.1ms 的气道闭合压(P_(0.1)),可用来估计 COPD 患者的神经肌肉驱动力,此时该驱动力常很高。急性呼吸衰竭期间,P_(0.1)的增高,表明吸气时神经肌肉活动增加。作者观察到急性呼吸衰竭时,P_(0.1)显著增加;而当病情恢复后,P_(0.1)则降低。因而提出:通过测定 P_(0.1)可判断神经肌肉驱动力,作为患者能否成功地停用呼吸机的一项重要指标。作者研究了12例接受辅助通气治疗的 COPD 患者,
During acute respiratory failure, the first 0.1 ms of airway closure pressure (P_ (0.1)) was used to estimate the neuromuscular driving force in COPD patients, and the driving force was often high. Increased P_ (0.1) during acute respiratory failure, indicating increased neuromuscular activity during inspiration. The authors observed a significant increase of P_ (0.1) in acute respiratory failure, while P_ (0.1) decreased when the condition recovered. Therefore, it is proposed that the neuromuscular driving force can be judged by measuring P_ (0.1) as an important indicator of whether the patient can successfully disable the ventilator. The authors studied 12 patients with COPD receiving adjuvant ventilation,