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硬纤维瘤的特点之一即为其临床进程的不可预知性,有些病例即使在肿瘤充分切除后仍有很高的复发倾向,而另一些病例即使无需治疗也会逐渐趋于稳定。这种截然不同的预后使得其治疗策略一直存在争议。目前一线的手术治疗已经引发争议。近10年来报道的术后5年局部复发率为25%～60%。硬纤维瘤的标准术式为切缘阴性的广泛切除,与软组织肉瘤的阳性切缘即预示复发不同,硬纤维瘤切缘阳性并非在所有报道中均为复发的危险因素。临床观察显示R0切除后患者仍有可能局部复发,而一些R1切除且未加辅
One of the hallmarks of the disease is the unpredictable nature of its clinical progression. Some cases have a high tendency to relapse even after full excision of the tumor, while others tend to stabilize even without treatment. This very different prognosis has led to controversy over its treatment strategy. The current frontline surgical treatment has been controversial. Over the past 10 years reported 5 years after the local recurrence rate was 25% to 60%. The standard surgical treatment of hard fibroids is a broad excision of negative margins, which is not the same as the positive margins of soft tissue sarcomas, which are not risk factors for recurrence in all reported cases. Clinical observation shows that patients with R0 resection may still be local recurrence, and some of the R1 resection without added