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目的 建立一种既能较好地模拟人类胃食管返流病 (GERD)的病理生理 ,又能快速可靠地诱发Barrett’s食管 (BE)和食管腺癌 (EAC)的动物模型。方法 SD大鼠 65只 ,通过手术产生十二指肠胃食管返流 (DGER)模型 ,分别于术后 1、4、8、12、16、2 0周随机抽取若干只大鼠 ,观察食管下段粘膜病变。结果 DGER模型术后 8、12、16、2 0周BE和EAC的发生率分别为 :33.3%和0 % ,62 .5 %和 12 .5 %、90 .0 %和 30 .0 %、86.6%和 5 3.3%。结论 我们建立的DGER模型能快速可靠地诱发BE和EAC ,是一种研究人类BE和EAC发生机制的较为理想的动物模型。
Objective To establish an animal model of Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC) that can both simulate the pathophysiology of human gastroesophageal reflux disease (GERD) well and quickly and reliably. Methods Sixty-five Sprague-Dawley rats were used to generate duodenal gastroesophageal reflux (DGER) model. Several rats were randomly selected at 1, 4, 8, 12, 16, and 20 weeks after operation to observe the lower esophageal mucosa. Lesions. Results The incidences of BE and EAC at 8, 12, 16 and 20 weeks after operation were respectively 33.3% and 0%, 62.5 % and 12.5%, 90.0 % and 30.0%, and 86.6. % and 5 3.3%. Conclusion The DGER model established by us can quickly and reliably induce BE and EAC. It is an ideal animal model to study the mechanism of human BE and EAC.