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Robinson医生问:1967年我开始行医时曾见过1例麻疹患儿,他在60年代初接种过旧的麻疹疫苗,同时还接受了丙种球蛋白。此后,我再未见过麻疹病例。直至最近,我们仍习惯于对15月龄儿童进行单剂初次接种,不管其近期有无感冒或其他病毒性疾病史或接种时正患有这类疾病。如果Krober等发现的“21%患感冒的婴儿不能产生可检出的麻疹抗体”是事实,那在我的行医过程中应碰到许多麻疹病例,或者无血清阳转并非是易感性的良好指标,不应以此来考虑是否需要进行麻疹加强免疫(目前建议在12岁时进行加强免疫)。
Dr. Robinson asks: I had seen 1 measles patient when I started practicing medicine in 1967. He had been vaccinated against the old measles vaccine in the early 1960s and also had gamma globulin. Since then, I have not seen measles cases again. Until recently, we were still accustomed to a single initial dose of 15-month-old children, whether they had a recent history of cold or other viral illness or were at the time of vaccination. If it is true that 21% of babies born with a cold can not detect detectable measles antibodies, as found by Krober et al., It is true that many measles cases should be encountered during my practice or that seroconversion is not a good indicator of susceptibility This should not be taken into account in order to consider the need for booster vaccination (currently recommended for booster vaccination at age 12).