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本文用计算机图像分析仪对73例食管鳞状上皮非典型增生的细胞核进行形态计量测量，检测了胞核面积、周长、形态因子、异形指数、园球等5个指标，并与正常组相对照，结果表明，传统的组织学分级与形态定量分级基本一致，有其客观性。同时发现组织学诊断与形态计量诊断间有一些病例交叉，即下级病变的测量指标高于上级病变均值或上级病变的测量指标低于下级病变均值的情况。如果具体到某一病人，多指标形态定量可能比组织学诊断更准确，更能代表病变的现状。本文从食管鳞癌发生学的角度，对组织学诊断、细胞学诊断及形态定量诊断相互之间的关系及意义作了深入的分析，认为对食管非典型增生细胞核进行多指标形态分析，可为临床诊疗及估计预后提供帮助。
In this paper, 73 cases of esophageal squamous epithelium atypical hyperplasia nuclei were measured with a computer image analyzer to measure the nucleus area, perimeter, form factor, heteromorphic index, round ball and other five indicators, and compared with the normal group. In contrast, the results show that the traditional histological grading is basically the same as the quantitative grading of morphology, and has its objectivity. At the same time, it was found that there were some cases where histological diagnosis and morphometric diagnosis were crossed. That is, the measurement index of lower-grade lesions was higher than that of upper-level lesions or the measurement of upper-level lesions was lower than that of lower-level lesions. If specific to a patient, multi-indicator morphometry may be more accurate than histological diagnosis, more representative of the status of the lesion. In this paper, from the perspective of esophageal squamous cell carcinoma, the relationship and significance between histological diagnosis, cytology diagnosis and quantitative diagnosis of morphology were analyzed in depth. It is considered that the multi-indicator morphological analysis of esophageal dysplasia nuclei can be performed. Provide clinical help and estimate prognosis.