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手性γ,γ-偕二芳基羰基化合物及其衍生物广泛存在于天然产物和药物分子中,如鬼臼毒素,Cladosporol和抗抑郁药舍曲林等.通常,手性γ,γ-偕二芳基羰基化合物的合成是以手性化合物为起始原料,通过催化不对称方式来构建这一关键骨架一直是一个挑战性的课题.铑催化芳基硼酸对芳基缺电子烯烃的不对称共轭加成是目前合成手性谐二芳基化合物有效途径之一.利用该策略,选用γ-芳基-β,γ-不饱和酮酸酯(或酮酰胺)类为底物,可能是实现手性γ,γ-偕二
Chiral γ, γ-gem-diaryl carbonyl compounds and their derivatives are widely found in natural products and drug molecules, such as podophyllotoxin, Cladosporol and antidepressant sertraline, etc. Usually, chiral γ, γ-kai The synthesis of diarylcarbonyl compounds is based on chiral compounds as the starting material, and it has been a challenging topic to construct this key skeleton through catalytic asymmetric method. Asymmetric aryl arylboronic acids Conjugate addition is one of the effective ways to synthesize chiral harmonic diaryl compounds.Using this strategy, the choice of γ-aryl-β, γ-unsaturated keto acid ester (or ketoamide) as the substrate may be Achieve chiral γ, γ-gelatin two