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目的:探讨p16/MTS1基因在子官内膜癌组织的表达及意义.方法:采用显微切割-聚合酶链反应方法,对29例子宫内膜癌组织和癌旁正常组织中p16/MTS1基因纯合缺失进行检测.并用Fisher精确检验的方法,对p16/MTS1基因纯合缺失与临床病理关系进行统计分析.结果:29例子宫内膜癌组织,p16/MTS1基因纯合缺失率为24.14%.Ⅰ期纯合缺失率为24.00%,Ⅱ期纯合缺失率为33.33%.结论:p16/MTS1基因纯合缺失与子宫内膜癌的发生有关.
Objective: To investigate the expression of p16 / MTS1 in endometrial carcinoma and its significance.Methods: The expression of p16 / MTS1 gene in 29 cases of endometrial carcinoma and adjacent normal tissues was detected by microdissection-polymerase chain reaction Homozygous deletion was detected, and the relationship between homozygous deletion of p16 / MTS1 gene and clinical pathology was analyzed by Fisher’s exact test.Results: The deletion rate of p16 / MTS1 gene homozygosity in 29 cases of endometrial carcinoma was 24.14% The rate of homozygous deletion in stage Ⅰ was 24.00%, and the rate of homozygous deletion in stage Ⅱ was 33.33% .Conclusion: The deletion of homozygous p16 / MTS1 gene is associated with the occurrence of endometrial carcinoma.