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强心甙中的洋地黄,在内科临床应用已2百多年。近十多年来由于同位素标记法和放射免疫测定法的应用,对于洋地黄各种制剂在体内的吸收、代谢和排泄过程,有了更进一步的了解。因而,对强心甙药物的相互作用也有了较深的认识。洋地黄类药物大多用于危重病人,是抢救病人关键性药物之一,合理的使用药物能消除疾病、增进病人健康。滥用药物或使用不当可能使疗效降低、毒副作用增加或引起医源性疾病,严重者反可贻误病人生命。近年来对此药物代谢的种属差异、个体差异、疾病的影响以及给药方法等问題已有不少的报道,本
Digitalis glycosides in digitalis clinical application in medicine has more than two hundred years. Over the past decade due to the application of isotope labeling and radioimmunoassay for digitalis various preparations in vivo absorption, metabolism and excretion process, have a better understanding. Thus, the interaction of cardiac glycosides drugs also have a deeper understanding. Digitalis drugs are mostly used in critically ill patients, is one of the key drugs to rescue patients, rational use of drugs to eliminate the disease, improve patient health. Misuse of drugs or improper use may reduce the efficacy, increase the side effects or cause iatrogenic diseases, serious cases can adversely affect the patient’s life. In recent years, there have been many reports on such issues as species differences, individual differences, disease effects and administration methods