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目的探讨后程三维适形大分割放疗联合化疗对局部晚期非小细胞肺癌(NSCLC)患者的疗效及耐受性。方法选取2012年1月至2014年1月收治的50例晚期NSCLC患者的临床资料,根据治疗方式不同,分为观察组(联合化疗)和对照组(单纯放疗),并对两组结果进行统计分析。结果观察组患者的治疗总有效率明显比对照组高(P<0.05)。观察组患者的1年局部控制率明显高于对照组(P<0.05),1、2年远处转移率均明显低于对照组(P<0.05)。观察组患者的1、2年生存率均明显高于对照组(P<0.05),中位生存期均明显较对照组长(P<0.05)。观察组患者治疗后的1、2和3级胃肠道反应和血液系统反应发生率均明显高于对照组(P<0.05)。结论后程三维适形大分割放疗联合化疗对局部晚期NSCLC患者的疗效明显,且患者耐受性较好。
Objective To investigate the efficacy and tolerability of posterior three-dimensional conformal radiotherapy combined with chemotherapy in patients with locally advanced non-small cell lung cancer (NSCLC). Methods The clinical data of 50 patients with advanced NSCLC who were admitted from January 2012 to January 2014 were divided into observation group (combined chemotherapy) and control group (radiotherapy alone) according to different treatment methods, and the results of two groups were statistically analyzed analysis. Results The total effective rate of observation group was significantly higher than that of control group (P <0.05). The 1-year local control rate in the observation group was significantly higher than that in the control group (P <0.05), and the distant metastasis rates in 1 and 2 years were significantly lower than those in the control group (P <0.05). The 1-year and 2-year survival rates of the observation group were significantly higher than those of the control group (P <0.05), and the median survival time was significantly longer than that of the control group (P <0.05). The incidences of gastrointestinal reactions and hematological reactions in the observation group after treatment were significantly higher than those in the control group (P <0.05). Conclusions Posterior procedural three-dimensional conformal radiofrequency radiation combined with chemotherapy has obvious curative effect on patients with locally advanced NSCLC, and the patients are well tolerated.