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目的了解四川省2004-2011年间急性弛缓性麻痹(acute flaccid paralysis,AFP)病例监测中残留麻痹病例的流行病学和病原学特征。方法对残留麻痹病例的脊灰减毒活疫苗(OPV)免疫史、年龄、发生的时间和粪便标本病毒学分离结果进行流行病学分析。结果 2004-2011年四川省共报告2 761例AFP病例,麻痹后60 d随访时351例病例仍有残留麻痹症状,占报告病例的12.71%,主要人群为6岁以下儿童(63.82%),男女性别比为1.74∶1;残留麻痹并采集到双份合格粪便标病例本中,脊髓灰质炎(脊灰)病毒(poliovirus,PV)阳性为11.73%,非脊灰肠道病毒(non-polio enterovirus,NPEV)阳性率为10.85%,PV阳性中以PVⅡ型最多。结论 2004-2011年四川省未发现脊灰野病毒引起的残留麻痹病例,在现阶段应进一步加强对NPEV的病原学和流行病学研究,找出儿童致残的主要病因。
Objective To understand the epidemiological and etiological characteristics of residual paralysis in the surveillance of acute flaccid paralysis (AFP) cases in Sichuan Province from 2004 to 2011. Methods Epidemiological analysis of the immunization history, age, time of occurrence and live virus isolation of live attenuated poliovirus (OPV) in residual paralysis cases were carried out. Results A total of 2 761 cases of AFP were reported in Sichuan Province from 2004 to 2011. There were still 351 cases of residual paralysis at 60 days after paralysis, accounting for 12.71% of the reported cases. The main population was 63.82% of children under 6 years old. The sex ratio was 1.74:1. The residual paralysis and double stool samples were collected. In this case, the poliovirus (PV) positive rate was 11.73%. The non-polio enterovirus , NPEV) positive rate was 10.85%, PV-positive PV II type in the most. Conclusion No cases of residual paralysis caused by poliovirus were found in Sichuan from 2004 to 2011. At present, the etiology and epidemiology of NPEV should be further strengthened to identify the major causes of disability in children.