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经鼻给甾体避孕药较其它惯用的肠道途径为优,可减少药物剂量。试验证明,该法对猴类有阻断排卵的作用。但临床应用30mg/天的孕酮或炔诺酮对抑制排卵的作用不够理想,本文旨在探讨鼻内给予较大剂量炔诺酮(NET)的耐受性及NET在用药周期中对生殖内分泌的作用。研究对象为6名20～29岁健康妇女、研究期使用非激素避孕法,并连续作4个月经周期研究。第
Nasal administration of steroid contraceptives is superior to other conventional gut routes and reduces the dose of the drug. Tests show that the Act has the role of blocking the monkey ovulation. However, the clinical application of 30 mg / day of progesterone or norethindrone is not ideal for the inhibition of ovulation. This paper aims to investigate the tolerability of intranasal administration of larger doses of norethindrone (NET) and the effect of NET on reproductive endocrine Role. Six healthy women, aged 20-29, were enrolled in the study. Non-hormonal contraception was used during the study period and four menstrual cycles were performed consecutively. No.