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目的探讨急性胰腺炎患者入院时凝血、纤溶相关指标与出院后血浆糖化血红蛋白(HbAlc)及C肽水平的相关性。方法入选2007年6月～2009年12月在普外科住院治疗的急性胰腺炎患者56例和同期门诊健康体检者非急性胰腺炎30例,检测所有实验对象血浆PT、APTT、FIB、D二聚体及出院后HbAlc及C肽水平,对AP患者入院时凝血、纤溶相关指标与出院3月后HbAlc及C肽水平进行Pearson直线相关分析。结果与对照组比较,AP患者血浆PT、APTT及D二聚体明显升高,两组间差异有统计学意义(P<0.05);AP患者入院时凝血、纤溶相关指标与出院3月后HbAlc及C肽水平存在相关性。结论 AP患者入院时血浆PT、APTT及D二聚体与出院3月后HbAlc正相关,与出院3月后血浆C肽水平呈负相关;提示AP组患者入院时血浆PT、APTT及D二聚体水平可能能预测AP患者出院后糖尿病的发生。
Objective To investigate the correlation between coagulation and fibrinolysis-related parameters and the plasma levels of HbAlc and C-peptide after admission in patients with acute pancreatitis. Methods Fifty-six patients with acute pancreatitis hospitalized in general surgery and 30 non-acute pancreatitis patients from outpatients during the same period were enrolled in this study from June 2007 to December 2009. All the subjects were tested for plasma PT, APTT, FIB, D dimerization Body and the level of HbAlc and C-peptide after discharge. The coagulation and fibrinolysis related indexes of AP patients admitted to hospital were compared with Pearson’s linear correlation analysis of HbAlc and C-peptide level after 3 months of discharge. Results Compared with the control group, the plasma levels of PT, APTT and D dimer in AP patients were significantly higher than those in the control group (P <0.05). The levels of coagulation and fibrinolysis in AP patients were significantly lower than those in the control group HbAlc and C peptide levels correlated. Conclusions The plasma PT, APTT and D-dimer in patients with AP were positively correlated with HbAlc at 3 months after discharge and negatively correlated with plasma C-peptide level at 3 months after discharge. It is suggested that plasma PT, APTT and D dimerization Body level may predict the occurrence of diabetic patients after AP discharge.